FeedDemon has a clean interface; is excellent for managing hundreds of feeds (or more); lets you set up watch lists; offers an online edition; syncs podcasts with iPods and other handheld media players.
FeedDemon is Windows only; doesn’t provide content sharing with other users.
FeedDemon is a terrific RSS reader that can handle hundreds of subscriptions faster and better than the many free Web-based readers available.
You can find more info on homepage
http://www.bradsoft.com/feeddemon/beta/